BDBM29589 Faridak::LBH-589::LBH-589B::Panobinostat::US10722597, Compound Panobinostat
SMILES Cc1[nH]c2ccccc2c1CCNCc1ccc(\C=C\C(=O)NO)cc1
InChI Key InChIKey=FPOHNWQLNRZRFC-ZHACJKMWSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 13 hits for monomerid = 29589
Affinity DataKi: 2.30nMAssay Description:Competitive inhibition of HDAC7 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataKi: 630nMAssay Description:Inhibition of human recombinant HDAC7 using fluorogenic HDAC substrate class 2a after 45 mins by fluorimetrc methodMore data for this Ligand-Target Pair
Affinity DataKi: 4.55E+3nMAssay Description:Inhibition of human HDAC7More data for this Ligand-Target Pair
Affinity DataIC50: 2.83E+3nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
Affinity DataIC50: 4.35E+3nMAssay Description:Inhibition of recombinant HDAC7 (unknown origin) using AMC labeled AC-peptide as substrate incubated for 1 hr by fluorescence analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.83E+3nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant HDAC7 (518 to end residues) expressed in baculovirus coexpressed in fall armyworm Sf9 cells usi...More data for this Ligand-Target Pair
Affinity DataIC50: 4.35E+3nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant HDAC7 (518 to end residues) expressed in baculovirus infected insect Sf9 cells using Ac-peptide...More data for this Ligand-Target Pair
Affinity DataIC50: 3.68E+3nMAssay Description:The inhibitory activity of panobinostat dissolved in DMSO and that of the HP-β-CD panobinostat adduct (prepared as described in Example 1) were ...More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human N-terminal GST-tagged HDAC7 (518 to end residues) expressed in baculovirus infected Sf9 cells using Ac-Leu-Gly-Lys(Tfa)-AMC as su...More data for this Ligand-Target Pair
Affinity DataIC50: 8.20nMAssay Description:Inhibition of HDAC7 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 531nMAssay Description:Inhibition of recombinant HDAC7 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 531nMAssay Description:Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundusMore data for this Ligand-Target Pair
Affinity DataIC50: 531nMAssay Description:Inhibition of human recombinant HDAC7 using Boc-Lys(triflouroacetyI)-AMC substrate incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair